boltz-api-cli

v0.1.1

Predict structures, screen molecules and proteins, and design binders.

Codex8 skills

by BoltzMIT5kupdated 3 weeks ago

Source

$ git clone https://github.com/openai/plugins

Clone the source, then follow the repository's marketplace instructions for your runtime. The plugin root is plugins/boltz-api-cli/ inside the repository.

Layout

plugins/boltz-api-cli/

├── .codex-plugin/plugin.json
├── skills/boltz-check-status/SKILL.md
├── skills/boltz-cli-setup/SKILL.md
├── skills/boltz-protein-design/SKILL.md
├── skills/boltz-protein-screen/SKILL.md
├── skills/boltz-small-molecule-adme/SKILL.md
├── skills/boltz-small-molecule-design/SKILL.md
├── skills/boltz-small-molecule-screen/SKILL.md
└── skills/boltz-structure-and-binding/SKILL.md

Skills8

boltz-check-statusskills/boltz-check-status/SKILL.md

Boltz job status and result recovery. Use when listing jobs, checking progress, resuming downloads, recovering results, or downloading an existing job ID. Not for starting new jobs.

boltz-cli-setupskills/boltz-cli-setup/SKILL.md

Boltz CLI setup and auth. Use when installing, updating, verifying, or authenticating `boltz-api`, or fixing missing CLI, PATH, sandbox, browser login, or auth errors.

boltz-protein-designskills/boltz-protein-design/SKILL.md

Design new protein binders with Boltz. Use when generating protein, peptide, antibody, nanobody, or custom binder candidates for a target. Not for screening existing proteins or small molecules.

boltz-protein-screenskills/boltz-protein-screen/SKILL.md

Screen existing protein binders with Boltz. Use when ranking a supplied protein, peptide, antibody, nanobody, or binder library against a target. Not for designing new proteins or screening small molecules.

boltz-small-molecule-admeskills/boltz-small-molecule-adme/SKILL.md

Predict Tier-1 ADME/ADMET for small molecules with Boltz from bare SMILES — no target, no docking. Use when the user wants solubility, permeability, or lipophilicity/logD for a molecule or list of molecules. Not for ranking molecules against a protein target (use boltz-small-molecule-screen, which already returns ADME free).

boltz-small-molecule-designskills/boltz-small-molecule-design/SKILL.md

Design new small-molecule binders with Boltz. Use when generating novel ligands or hits for a target without a fixed compound library. Not for screening existing molecules or one-off docking.

boltz-small-molecule-screenskills/boltz-small-molecule-screen/SKILL.md

Screen existing small-molecule libraries with Boltz. Use when docking, scoring, or ranking a supplied SMILES or compound library against a target; also returns free Tier-1 ADME/ADMET (solubility, permeability, lipophilicity/logD) per molecule. Not for de novo molecule design, one-off docking, or ADME on bare SMILES with no target (use boltz-small-molecule-adme).

boltz-structure-and-bindingskills/boltz-structure-and-binding/SKILL.md

Predict structures and binding for one defined complex with Boltz. Use when folding a protein, RNA, DNA, or ligand complex, docking one ligand, predicting an interface, or scoring binding. Not for screening libraries or design.

Manifests1

plugins/boltz-api-cli/.codex-plugin/plugin.json

{
  "name": "boltz-api-cli",
  "version": "0.1.1",
  "description": "Predict structures, screen molecules and proteins, and design binders.",
  "author": {
    "name": "Boltz",
    "email": "support@boltz.bio",
    "url": "https://boltz.bio"
  },
  "homepage": "https://boltz.bio",
  "repository": "https://github.com/boltz-bio/boltz-api-skills",
  "license": "MIT",
  "keywords": [
    "boltz",
    "boltz-api",
    "go-cli",
    "computational-biology",
    "protein-design",
    "protein-screening",
    "small-molecule-design",
    "virtual-screening",
    "structure-prediction",
    "molecular-modeling",
    "drug-discovery",
    "biotech"
  ],
  "skills": "./skills",
  "interface": {
    "displayName": "Boltz",
    "shortDescription": "Predict structures, screen molecules and proteins, and design binders",
    "longDescription": "Use Boltz from Codex for biomolecular modeling workflows: predict structure and binding for protein, RNA, DNA, and ligand complexes; rank small-molecule or protein libraries against targets; and design novel small molecules, peptides, antibodies, nanobodies, or custom protein binders with structures and confidence metrics.",
    "developerName": "Boltz",
    "category": "Education & Research",
    "capabilities": [
      "Interactive",
      "Write"
    ],
    "websiteURL": "https://boltz.bio",
    "privacyPolicyURL": "https://boltz.bio/privacy",
    "termsOfServiceURL": "https://boltz.bio/terms",
    "brandColor": "#4e6d53",
    "composerIcon": "./assets/app-icon.png",
    "logo": "./assets/app-icon.png",
    "screenshots": [],
    "defaultPrompt": [
      "Predict EGFR L858R binding to osimertinib",
      "Design nanobodies for a SARS-CoV-2 RBD epitope",
      "Design selective JAK2 binders from Enamine REAL"
    ]
  }
}